Investigating the Molecular Basis of T-Cell Receptor Cross-Reactivity

Grant number: DP110102078 | Funding period: 2011 - 2013

Completed

Abstract

This project will explore the basis of unexpected immune reactions whereby the immune system mistakes one molecular structure for another, a phenomenon known as cross-reactivity. This project will examine how often this is due to molecular mimicry, potentially explaining why immune T cells sometimes react inappropriately to different agents.

Related publications (1)

Highly divergent T-cell receptor binding modes underlie specific recognition of a bulged viral peptide bound to a human leukocyte antigen class I molecule

YC Liu, JJ Miles, MA Neller, E Gostick, DA Price, AW Purcell, J McCluskey, SR Burrows, J Rossjohn, S Gras

2013-05-31

Human leukocyte antigen (HLA)-I molecules can present long peptides, yet the mechanisms by which T-cell receptors (TCRs) recognize..

University of Melbourne Researchers

McCluskey James